تفاعل #503151

معادلة التفاعل

4-Amino-5-iodo-2-trifluoromethyl-benzonitrile

Cs2CO3

1,10-phenanthroline

→

4-Amino-5-methoxy-2-trifluoromethyl-benzonitrile

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was refluxed overnight
2. 2
   أخرىthe solvent was removed under vacuum
3. 3
   أخرىUpon separation on silica gel (100% CH2Cl2)
4. 4
   أخرىthe tile compound was obtained as a colorless liquid

الإجراء التجريبي

4-Amino-5-iodo-2-trifluoromethyl-benzonitrile (312 mg, 1.0 mmol), CuI (I) (20 mg, 0.1 mmol), Cs2CO3 (652 mg, 2.0 mmol) and 1,10-phenanthroline (36 mg, 0.2 mmol) were mixed in methanol (20 ml). The reaction mixture was refluxed overnight and then the solvent was removed under vacuum. Upon separation on silica gel (100% CH2Cl2), the tile compound was obtained as a colorless liquid.

المصدر