تفاعل #50302

معادلة التفاعل

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromomethylthiazolidine

potassium t-butoxide

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-methylthiazoline

المردود 64.0%

المذيبات

t-butanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter removal of the solvent under reduced pressure
2. 2
   استخلاصthe concentrated residue was extracted with chlorofom (100 ml)
3. 3
   غسيلwashed with water
4. 4
   تجفيفdried over anhydrous magnesium sulfate
5. 5
   أخرىThe solvent was removed under reduced pressure

الإجراء التجريبي

A solution of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromomethylthiazolidine (0.7 g) and potassium t-butoxide (0.25 g) in t-butanol (30 ml) was refluxed for 5 hours. After removal of the solvent under reduced pressure, the concentrated residue was extracted with chlorofom (100 ml), washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure,-and the residue was subjected to column chromatography to give 0.36 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound No. 1).

المصدر