تفاعل #5030

معادلة التفاعل

7-Nitro-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid

potassium carbonate

methyl iodide

→

compound

المردود 100.4%

7-Nitro-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid methyl ester

المردود 100.4%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter the insoluble matter was filtered off
2. 2
   تركيزthe filtrate was concentrated
3. 3
   workup.ADDITIONethyl acetate (500 ml) was added to the residue, which
4. 4
   غسيلwas then washed with water
5. 5
   تجفيفdried over anhydrous sodium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off

الإجراء التجريبي

7-Nitro-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid (6.25 g) was dissolved into DMF (50 ml), to which then potassium carbonate (11 g) and methyl iodide (4.9 ml) were added, and was stirred for 2 hours at room temperature. After the insoluble matter was filtered off and the filtrate was concentrated, ethyl acetate (500 ml) was added to the residue, which was then washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off to give the intended compound 6.65 g (quantitatively) as yellow crystal.

المصدر