تفاعل #502508

معادلة التفاعل

methyl 3-(1-azabicyclo[3.2.1]octane-5-carboxamido)-2-hydroxybenzoate

→

methyl 2-(1-azabicyclo[3.2.1]octan-5-yl)benzo[d]oxazole-7-carboxylate

المردود 21.3%

المذيبات

proponic acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux for 2 days
2. 2
   تركيزThe resulting solution was concentrated under vacuum
3. 3
   أخرىthe crude product was purified by column chromatography (silica gel, petroleum ether/ethyl acetate 20:1 to 2:1)

الإجراء التجريبي

A solution of methyl 3-(1-azabicyclo[3.2.1]octane-5-carboxamido)-2-hydroxybenzoate (500 mg, 1.64 mmol) in proponic acid 10 ml) was heated to reflux for 2 days. The resulting solution was concentrated under vacuum, the crude product was purified by column chromatography (silica gel, petroleum ether/ethyl acetate 20:1 to 2:1), 100 mg methyl 2-(1-azabicyclo[3.2.1]octan-5-yl)benzo[d]oxazole-7-carboxylate was obtained. Yield: 21%. LC-MS (ESI) (m/z): 287 (M+1)+.

المصدر