تفاعل #5023

معادلة التفاعل

ethanol

N-acetyl-5-bromo-7-nitroindoline

hydrochloric acid

→

compound

المردود 32.2%

N-acetyl-7-amino-5-bromoindoline

المردود 32.2%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto refluxing for 5 hours with vigorous stirring
2. 2
   ترشيحThe reaction mixture was filtered by suction while hot
3. 3
   أخرىto remove insoluble matter
4. 4
   تركيزthe filtrate thereof was concentrated
5. 5
   درجة الحرارةcooled

الإجراء التجريبي

To a mixed solution of ethanol (400 ml) and water (100 ml), were added N-acetyl-5-bromo-7-nitroindoline (133.1 g), iron powder (10 mesh; 75 g) and concentrated hydrochloric acid (5 ml), and the mixture was subjected to refluxing for 5 hours with vigorous stirring. The reaction mixture was filtered by suction while hot to remove insoluble matter, and then the filtrate thereof was concentrated and cooled on standing to give the intended compound 38.3 g (32.2%) as a brown needle crystal. M.P.: 154°-155° C.

المصدر