تفاعل #502111

معادلة التفاعل

((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methan-1-ol

triethylamine

tert-butylchlorodiphenylsilane

→

title compound

المردود 106.2%

1-(((4S)-2,2-Dimethyl(1,3-dioxolan-4-yl))methoxy)-2,2-dimethyl-1,1-diphenyl-1-silapropane

المردود 106.2%

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلthe reaction mixture was washed with water, brine
2. 2
   تجفيفdried over sodium sulfate
3. 3
   ترشيحfiltered
4. 4
   أخرىevaporated

الإجراء التجريبي

To a solution of ((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methan-1-ol (9 g, 68.6 mmol) in anhydrous dichloromethane (40 mL) were added triethylamine (11.2 mL), tert-butylchlorodiphenylsilane (19.8 g, 372 mmol), and N,N-dimethylaminopyridine (DMAP, 418 mg, 3.4 mmol) at room temperature under a nitrogen atmosphere. The reaction mixture was stirred at room temperature overnight. It was then diluted with additional dichloromethane and the reaction mixture was washed with water, brine, dried over sodium sulfate, filtered and evaporated to give the title compound (27 g) which was used in the next step without further purification.

المصدر