تفاعل #502102

معادلة التفاعل

[4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol

hydrochloric acid

→

compound

[4-[(2-Quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol hydrochloride

المذيبات

dichloromethane

isopropanol

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONare added to the filtrate
2. 2
   تركيزThe reaction mixture is then concentrated under reduced pressure
3. 3
   ترشيحThe precipitate is recovered by filtration
4. 4
   أخرىoven-dried under reduced pressure

الإجراء التجريبي

100 mg of [4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol are suspended in dichloromethane and methanol. The solution is passed through a frit and 5.6 ml of a 0.1N solution of hydrochloric acid in isopropanol are added to the filtrate. The reaction mixture is then concentrated under reduced pressure and the residue is then taken up in diethyl ether. The precipitate is recovered by filtration and oven-dried under reduced pressure. 106 mg of compound are obtained.

المصدر