تفاعل #502098

معادلة التفاعل

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine

2-bromo-1-(4-chlorophenyl)ethanone

sodium hydrogen carbonate

→

compound

المردود 93.2%

2-(4-Chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

المردود 93.2%

المذيبات

n-propanol

ظروف التفاعل

المعالجة

1. 1
   workup.WAITThe reaction mixture is left
2. 2
   درجة الحرارةto cool
3. 3
   تركيزconcentrated under reduced pressure
4. 4
   أخرىthe organic phase is then separated
5. 5
   تجفيفdried over magnesium sulphate
6. 6
   أخرىthe solvent is then evaporated off under reduced pressure

الإجراء التجريبي

2.5 g of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine and 2.65 g of 2-bromo-1-(4-chlorophenyl)ethanone in 76 ml of n-propanol are placed in a round-bottomed flask. 1.33 g of sodium hydrogen carbonate are added thereto. The mixture is heated at 80° C. for 16 h. The reaction mixture is left to cool and concentrated under reduced pressure. The residue is taken up between water and ethyl acetate, the organic phase is then separated by settling out and dried over magnesium sulphate, and the solvent is then evaporated off under reduced pressure. 3.75 g of compound are obtained.

المصدر