تفاعل #502096

معادلة التفاعل

2-(4-chlorophenyl)-6-iodoimidazo[1,2-a]pyridine

5-formyl-2-furanboronic acid

potassium carbonate

ethanol

→

compound

المردود 38.2%

5-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde

المردود 38.2%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىdegassed with argon
2. 2
   أخرىirradiated at 90° C. for 30 min
3. 3
   درجة الحرارةAfter cooling
4. 4
   أخرىthe catalyst is removed by filtration
5. 5
   غسيلwashed with ethyl acetate
6. 6
   أخرىThe organic phase is separated
7. 7
   أخرىdried
8. 8
   تركيزthe filtrate is concentrated under reduced pressure
9. 9
   أخرىThe residue is purified by silica gel chromatography, elution

الإجراء التجريبي

300 mg of 2-(4-chlorophenyl)-6-iodoimidazo[1,2-a]pyridine, 118 mg of 5-formyl-2-furanboronic acid, 89 mg of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium, 280 mg of potassium carbonate, 1.5 ml of ethanol and 1 ml of water are placed in a microwave tube and degassed with argon. The tube is placed in a microwave apparatus and irradiated at 90° C. for 30 min. After cooling, the catalyst is removed by filtration and washed with ethyl acetate. The organic phase is separated and dried and the filtrate is concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a dichloromethane/methanol mixture. 104 mg of compound are obtained.

المصدر