تفاعل #502083

ord-0a66b2c927b04473a72ca051f029c794

معادلة التفاعل

COC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C
Boc-Lys(Cbz)-OMe
CCOC(C)=O
Ethyl acetate
→
COC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C
Boc-Lys-OMe

المتفاعلات

COC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C
Boc-Lys(Cbz)-OMe
CCOC(C)=O
Ethyl acetate

الكواشف

[Pd]
Palladium

المذيبات

CO
MeOH

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    ترشيحThe organic solution was filtered through Celite
  2. 2
    غسيلwashed with 10 mL MeOH
  3. 3
    أخرىThe filtrate was evaporated under reduced pressure

الإجراء التجريبي

1.0 g of Boc-Lys(Cbz)-OMe (5) was dissolved in 40 mL MeOH:Ethyl acetate. 100 mg of Palladium on active carbon (Pd/C) was added to the solution. The solution was stirred under hydrogen for 2 hrs. The organic solution was filtered through Celite and washed with 10 mL MeOH. The filtrate was evaporated under reduced pressure to yield Boc-Lys-OMe of formula (6)

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08088757B2uspto-grants-2012_01