تفاعل #50165

معادلة التفاعل

tetrahydrofuran

compound ( 30 )

4-(1-methylbutyloxy)benzaldehyde

THF

butyllithium

bromide

→

1-(2-methoxyethenyl)-4-(1-methylbutyloxy)benzene

المذيبات

hexane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added to a solution
2. 2
   workup.ADDITIONwas added
3. 3
   workup.STIRRINGstirring
4. 4
   workup.WAITwas continued for two hours
5. 5
   غسيلThe reaction solution was washed with water
6. 6
   تجفيفwas dried over magnesium sulfate
7. 7
   تركيزwas then concentrated
8. 8
   أخرىThe residue was purified by column chromatography

الإجراء التجريبي

A solution containing butyllithium dissolved in hexane was added to a solution containing 120 g of methoxymethyltriphenylphosphoni bromide dissolved in tetrahydrofuran (THF), in an atmosphere of argon, and the mixture was stirred for one hour at room temperature. A solution of the compound (30) dissolved in THF was added thereto and stirring was continued for two hours. The reaction solution was washed with water, was dried over magnesium sulfate, and was then concentrated. The residue was purified by column chromatography to obtain 1-(2-methoxyethenyl)-4-(1-methylbutyloxy)benzene (31).

المصدر