تفاعل #50160

معادلة التفاعل

Water

2-ethylimidazole

triethylamine

dimethylsulfamoyl chloride

→

1-dimethylsulfamoyl-2-ethylimidazole

المردود 86.1%

المذيبات

chloroform

chloroform

ظروف التفاعل

المعالجة

1. 1
   أخرىis separated
2. 2
   تركيزconcentrated
3. 3
   workup.DISSOLUTIONThe residue is dissolved in ethyl acetate (1 liter)
4. 4
   غسيلwashed with water
5. 5
   تجفيفdried over sodium sulfate
6. 6
   تركيزconcentrated
7. 7
   workup.DISTILLATIONDistillation

الإجراء التجريبي

To a stirred solution of 2-ethylimidazole (100 g) and triethylamine (115 g) in chloroform (800 ml) at 0° C. is added a solution of dimethylsulfamoyl chloride (153 g) in chloroform (200 ml). The mixture is stirred overnight at room temperature. Water (1.5 liter) is added to the reaction mixture after which the organic layer is separated and concentrated. The residue is dissolved in ethyl acetate (1 liter) and washed with water, and then dried over sodium sulfate and concentrated. Distillation gives 1-dimethylsulfamoyl-2-ethylimidazole (182 g) as a colorless liquid.

المصدر