تفاعل #50152

معادلة التفاعل

ethyl 2-n-propyl-3-[2'-(t-butoxycarbonyl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate

potassium carbonate

allyl bromide

tetrahydrofuran

→

ethyl 2-n-propyl-5-allyl-3-[2'-(t-butoxycarbonyl)biphenyl- 4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate

المردود 59.3%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   غسيلthe mixture is washed
2. 2
   أخرىdried
3. 3
   أخرىevaporated
4. 4
   أخرىThe residue is purified by silica gel column chromatography (solvent; chloroform/methanol)

الإجراء التجريبي

A mixture of ethyl 2-n-propyl-3-[2'-(t-butoxycarbonyl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate (0.20 g), potassium carbonate (0.082 g), allyl bromide (0.057 g) and tetrahydrofuran (2 ml) is stirred overnight at room temperature. To the mixture is added chloroform, and the mixture is washed, dried and evaporated. The residue is purified by silica gel column chromatography (solvent; chloroform/methanol) to give ethyl 2-n-propyl-5-allyl-3-[2'-(t-butoxycarbonyl)biphenyl- 4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate (0.128 g).

المصدر