تفاعل #50137

معادلة التفاعل

compound

methyl 2-n-butyl-3-(2'-methoxycarbonylbiphenyl-4-yl)methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate

acetic anhydride

→

methyl 2-n-butyl-5-acetyl-3-(2'-methoxycarbonylbiphenyl-4-yl)methyl-4,5,6,7-tetrahydroimidazo[4,5-c] pyridine-4-carboxylate

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONThe solvent is distilled off
2. 2
   workup.ADDITIONto the resulting residue is added chloroform
3. 3
   غسيلthe mixture is washed
4. 4
   أخرىdried
5. 5
   أخرىevaporated
6. 6
   أخرىto remove the solvent
7. 7
   أخرىThe residue is purified by silica gel column chromatography (solvent; chloroform/ethanol=10:1)

الإجراء التجريبي

To a mixture of the compound obtained in Example 12 (1.70 g) and pyridine (20 ml) is added acetic anhydride (5 ml), and the mixture is stirred overnight. The solvent is distilled off, and to the resulting residue is added chloroform, and the mixture is washed, dried, and evaporated to remove the solvent. The residue is purified by silica gel column chromatography (solvent; chloroform/ethanol=10:1) to give methyl 2-n-butyl-5-acetyl-3-(2'-methoxycarbonylbiphenyl-4-yl)methyl-4,5,6,7-tetrahydroimidazo[4,5-c] pyridine-4-carboxylate (0.47 g) as an oil. NMR (CDCl3) δ: 0.88 (3H, t), 2.21 (3H, s), 3.46 (3H, s), 3.64 (3H, s), 5.33 (2H, ABq)

المصدر