تفاعل #5012

معادلة التفاعل

H2SO4

diethyl 2-methylbenzylphosphonate

KMnO4

Na2CO3

→

Diethyl 2-carboxybenzylphosphonate

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux for 24 hours
2. 2
   استخلاصextracted five times with 300 ml of ether each time
3. 3
   تجفيفThe organic phase was dried over MgSO4
4. 4
   أخرىthe solvent was evaporated off on a rotary evaporator
5. 5
   أخرىthe residue was chromatographed over silica gel (CH2Cl2 /methanol/triethylamine 9/1/0.1)

الإجراء التجريبي

4 g of diethyl 2-methylbenzylphosphonate were added to a solution of 12 g of KMnO4 and 4 g of Na2CO3 in 300 ml of water and the mixture was boiled under reflux for 24 hours. It was acidified with 15 ml of concentrated H2SO4 and extracted five times with 300 ml of ether each time. The organic phase was dried over MgSO4, the solvent was evaporated off on a rotary evaporator and the residue was chromatographed over silica gel (CH2Cl2 /methanol/triethylamine 9/1/0.1).

المصدر