تفاعل #501

معادلة التفاعل

COC(=O)c1cc(Br)ccc1I

C1COCCN1

→

COC(=O)c1cc(Br)ccc1N

المردود 17.9%

المذيبات

COCCOC

ظروف التفاعل

الإجراء التجريبي

To a solution of methyl 5-bromo-2-iodobenzoate (2.1 g, 6.16 mmol) in DME (15 mL) were morpholine (0.593 mL, 6.78 mmol), rac-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (0.384 g, 0.62 mmol), Palladium acetate (0.138 g, 0.62 mmol) and CESIUM CARBONATE (2.81 g, 8.62 mmol) added. The mixture was heated in the microwave oven for 1h. The solvent was evaporated and the crude product was added to a silica gel column, 0-25% EtOAc in heptane yielding [Products]

المصدر