تفاعل #50098

ord-82bd3a41a9f147679decbb201340163b

معادلة التفاعل

CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)[C@H](Cc1ccc(N(CCCl)CCCl)cc1)NC(=O)OC(C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
product
CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)[C@H](Cc1ccc(N(CCCl)CCCl)cc1)NC(=O)OC(C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
1,2-Distearoyl-3-{(S)-N-tert-butoxycarbonyl-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol
→
CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)[C@@H](N)Cc1ccc(N(CCCl)CCCl)cc1)OC(=O)CCCCCCCCCCCCCCCCC
expected product
CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)[C@@H](N)Cc1ccc(N(CCCl)CCCl)cc1)OC(=O)CCCCCCCCCCCCCCCCC
1,2-Distearoyl-3-{(S)-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol

المتفاعلات

CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)[C@H](Cc1ccc(N(CCCl)CCCl)cc1)NC(=O)OC(C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
product
CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)[C@H](Cc1ccc(N(CCCl)CCCl)cc1)NC(=O)OC(C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
1,2-Distearoyl-3-{(S)-N-tert-butoxycarbonyl-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol

الكواشف

لا شيء

المذيبات

Cl
hydrogen chloride

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    تركيزThe whole mixture is concentrated under vacuum
  2. 2
    غسيلthe residue is washed with pentane

الإجراء التجريبي

A solution of 5 mmol of the product obtained in Example 1 in 25 ml of hydrogen chloride-saturated dioxane is stirred for 20 minutes at 20° C. The whole mixture is concentrated under vacuum and the residue is washed with pentane, to give the expected product in hydrochloride form.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US05424464uspto-grants-1995_06