تفاعل #500903

معادلة التفاعل

triethylamine

benzyl glycinate hydrochloride

4-methylpiperazin-1-ylcarbonyl chloride hydrochloride

→

benzyl N-(4-methylpiperazin-1-ylcarbonyl)-glycinate

المردود 43.5%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   تركيزthe reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa)
2. 2
   غسيلThe organic phase is successively washed with twice 100 cm3 of a saturated aqueous sodium bicarbonate solution and 70 cm3 of water
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated to dryness under reduced pressure (2.7 kPa)

الإجراء التجريبي

4.2 cm3 of triethylamine and 3.02 g of benzyl glycinate hydrochloride are added, at 20° C., to 3 g of 4-methylpiperazin-1-ylcarbonyl chloride hydrochloride in solution in 150 cm3 of tetrahydrofuran. After stirring for 16 hours at 60° C., the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa) and the residue is taken up in 70 cm3 of dichloromethane. The organic phase is successively washed with twice 100 cm3 of a saturated aqueous sodium bicarbonate solution and 70 cm3 of water, and then dried over magnesium sulfate, filtered and concentrated to dryness under reduced pressure (2.7 kPa) to give 1.9 g of benzyl N-(4-methylpiperazin-1-ylcarbonyl)-glycinate in the form of a white solid.

المصدر