تفاعل #50023

معادلة التفاعل

trimethyl orthoformate

L-Proline

sulfuryl chloride

→

product

L-Proline Methyl Ester Hydrochloride

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.WAITAfter 16 hours at room temperature
2. 2
   درجة الحرارةanother 4 hours at reflux
3. 3
   درجة الحرارةheating
4. 4
   درجة الحرارةat reflux
5. 5
   workup.WAITcontinued for another 24 hr
6. 6
   تركيزThe reaction mixture was then concentrated
7. 7
   workup.WAITthe resultant oil was placed under high vacuum for several days

الإجراء التجريبي

To a solution of L-Proline (115 g,1 mol) in methanol (1.2 L) at 0° C. was added sulfuryl chloride (45 mL, 0.55 mol) slowly during ~15-20 min, then the reaction mixture stirred overnight at room temperature. After 16 hours at room temperature and another 4 hours at reflux, trimethyl orthoformate (120 mL, 1.1 mol) was added and heating at reflux continued for another 24 hr. The reaction mixture was then concentrated and the resultant oil was placed under high vacuum for several days to afford the product as a clear oil (205 g).

المصدر