تفاعل #50015

معادلة التفاعل

(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone

triethylamine

thiolacetic acid

→

(±)-1-acetyl-4-acetylthio-2-pyrrolidone

المردود 90.0%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture is refluxed for three hours
2. 2
   غسيلThe reaction solution is washed with water
3. 3
   أخرىdried
4. 4
   أخرىevaporated
5. 5
   أخرىto remove the solvent

الإجراء التجريبي

(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone (3 g) and triethylamine (2.1 ml) are dissolved in ethyl acetate (30 ml), and the mixture is refluxed for three hours, and then allowed to stand at room temperature for 8 hours. To the reaction solution is added thiolacetic acid (1.2 ml), and the mixture is stirred at room temperature for 5 hours. The reaction solution is washed with water, dried, and evaporated to remove the solvent to give (±)-1-acetyl-4-acetylthio-2-pyrrolidone (2.7 g).

المصدر