تفاعل #499991

معادلة التفاعل

K3PO4

Bromobenzene

4-chlorophenylboronic acid

→

title compound

المردود 78.0%

4-Chloro-1,1′-biphenyl

المردود 78.0%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىat 100° C.

الإجراء التجريبي

Bromobenzene (80 mg, 0.51 mmol) reacted with 4-chlorophenylboronic acid (103 mg, 0.66 mmol) using 0.5/1.0 mol % of Pd(dba)2/Ph5FcP(t-Bu)2 and K3PO4 (318 mg, 1.50 mmol) in toluene at 100° C. to give the title compound (75 mg, 78%) as a white solid: 1H-NMR (400 MHz, CDCl3): δ 7.41-7.62 (m, 9H). 13C{1H}-NMR (100 MHz, CDCl3): δ 139.95, 139.62, 133.33, 128.88, 128.86, 128.36, 127.56, 126.96. GC/MS(EI): m/z 188 (M+), 152

المصدر