تفاعل #49960

معادلة التفاعل

3-Phenyl-l-adamantaneacetic acid

Methyl 3-bromoadamantaneacetate

Aluminum trichloride

→

methyl 3-phenyl-1-adamantaneacetate

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L)
2. 2
   أخرىThe layers were separated
3. 3
   تجفيفthe organic layer was dried over sodium sulfate
4. 4
   ترشيحfiltered
5. 5
   أخرىevaporated in vacuo

الإجراء التجريبي

Preparation of 3-Phenyl-l-adamantaneacetic acid, a hapten. Methyl 3-bromoadamantaneacetate (80 g) (Aldrich Chemical Co. Milwaukee Wis.) was dissolved in benzene (1.6 L) under nitrogen. Aluminum trichloride (37.12 g) was added portionwise over 75 min. at ambient temperature. The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L). The layers were separated and the organic layer was dried over sodium sulfate, filtered, and evaporated in vacuo to give methyl 3-phenyl-1-adamantaneacetate (80 g).

المصدر