تفاعل #4994

معادلة التفاعل

3-ethylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

hydroxyamine hydrochloride

→

desired product

المردود 85.0%

3-(alpha-hydroxyiminopropyl)-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

المردود 85.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was heated
2. 2
   درجة الحرارةto reflux for 4 hours
3. 3
   أخرىAfter evaporation of methanol, water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   استخلاصThe aqueous solution was extracted with ethylacetate
6. 6
   أخرىAfter evaporation of ethylacetate
7. 7
   أخرىthe residue was purified by column chromatography(benzene:ether=1.1)

الإجراء التجريبي

0.9 g of 3-ethylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole and 0.21 g of hydroxyamine hydrochloride were added to 10 ml of methanol. The mixture was heated to reflux for 4 hours. After evaporation of methanol, water was added to the residue. The aqueous solution was extracted with ethylacetate. After evaporation of ethylacetate, the residue was purified by column chromatography(benzene:ether=1.1) to provide 0.80 g of the desired product(yield: 85.0%).

المصدر