تفاعل #49843
ord-d03018394fe041c8b75f8e996360287f
معادلة التفاعل
5-bromopyridin-3-ylmethanol
tert-butylchlorodiphenylsilane
imidazole
→
product
5-Bromo-O-tert-butyldiphenylsilylpyridin-3-ylmethanol
الكواشف
لا شيء
المذيبات
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1ترشيحand filtered
- 2أخرىThe filtrate was evaporated
- 3أخرىthe residue chromatographed on silica gel eluting with a 1:7 mixture of EtOAc and hexane
الإجراء التجريبي
To a solution of 5-bromopyridin-3-ylmethanol (Chem. Pharm. Bull. 1990, 38, 2446) (29 g, 154 mmoL) and tert-butylchlorodiphenylsilane (47.5 g, 173 mmoL) in CH2Cl2 (500 mL) at r.t., there was added imidazole (15.8 g, 232 mmoL). The mixture was stirred for 1 hr. and filtered. The filtrate was evaporated and the residue chromatographed on silica gel eluting with a 1:7 mixture of EtOAc and hexane, to afford the product as a colorless oil.