تفاعل #49803

معادلة التفاعل

water

Benzyl alcohol

triethylamine

{o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetyl chloride

→

title product

المردود 77.8%

Benzyl {o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetate

المردود 77.8%

المذيبات

tetrahydrofuran

—

hexanes

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ether
2. 2
   غسيلThe combined organic extracts are washed sequentially with one molar hydrochloric acid, water and brine
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىto obtain an oil

الإجراء التجريبي

Benzyl alcohol (0.8 mL, 7.73 mmol) and triethylamine (1 mL, 7.17 mmol) are added to a mixture of {o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetyl chloride (1.12 g, 2.38 mmol) in tetrahydrofuran. The reaction mixture is stirred for twenty minutes, poured into water and extracted with ether. The combined organic extracts are washed sequentially with one molar hydrochloric acid, water and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to obtain an oil. Column chromatography of the oil using silica gel and a hexanes in methylene chloride solution gives the title product as a yellow oil (1.0 g) which is identified by NMR spectral analyses.

المصدر