تفاعل #49770

معادلة التفاعل

2,6-lutidine

→

DBU

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction

الإجراء التجريبي

A mixture of 5.0 g of product of Step 3 and 2.13 g of 2,6-lutidine is heated at 143° C. for 30 minutes. Two drops of DBU are added and the reaction mixture is heated for additional 1 hour and 30 minutes, cooled and worked up as in (b) above to give 4.23 g of the desired product. The reaction can also be carried out in excess of 2,6-lutidine and a catalytic amount of DBU without solvent or in the presence of toluene as solvent giving similar results.

المصدر