تفاعل #49754

معادلة التفاعل

hydrochloric acid

methyl N-(2-fluoro-4-chloro-5-isobutyloxycarbonyloxyphenyl)carbamate

3-methylcyclopentyl p-toluenesulfonate

potassium carbonate

→

methyl N-{2-fluoro-4-chloro-5-(3-methylcyclopentyl)oxyphenyl}carbamate

المردود 75.2%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder refluxing
2. 2
   أخرىAfter completion of the reaction
3. 3
   استخلاصthe mixture was extracted with ethyl acetate (50 ml×3 times)
4. 4
   أخرىThe organic layer was dried
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

الإجراء التجريبي

A solution of methyl N-(2-fluoro-4-chloro-5-isobutyloxycarbonyloxyphenyl)carbamate (5.37 g, 16.8 mmol) prepared by the process as shown in Reference Example 3, 3-methylcyclopentyl p-toluenesulfonate (5.0 g, 20.2 mmol) and potassium carbonate (2.32 g, 16.8 mmol) in methanol (50 ml) was stirred for 5 hours under refluxing. After completion of the reaction, the reaction mixture was poured into 1N hydrochloric acid (100 ml), and the mixture was extracted with ethyl acetate (50 ml×3 times). The organic layer was dried, and the solvent was distilled off under reduced pressure to obtain methyl N-{2-fluoro-4-chloro-5-(3-methylcyclopentyl)oxyphenyl}carbamate as grey white crystals (3.81 g, 12.6 mmol, 75.2% yield). 1H-NMR Spectrum (CDCl3, TMS, ppm): δ1.02 and 1.08 (total 3H, d, J=6.0 Hz), 1.25-2.40 (7H, m), 3.77 (3H, s), 4.75 (1H, m), 6.68 (1H, br, s) 7.05 (1H, d, JHF =10.5 Hz), 7.75 (1H, d, JHF =7.5 Hz).

المصدر