تفاعل #49753

معادلة التفاعل

2-fluoro-4-chloro-5-cyclopentyloxynitrobenzene

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2-fluoro-4-chloro-5-cyclopentyloxyaniline

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىthe mixture was reacted at room temperature to 70° C. under a hydrogen pressure of 3 to 5 atms
2. 2
   أخرىAfter absorption of hydrogen gas
3. 3
   أخرىthe catalyst was removed by filtration
4. 4
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure from the filtrate

الإجراء التجريبي

The resulting 2-fluoro-4-chloro-5-cyclopentyloxynitrobenzene (13.0 g, 50.1 mmol) was dissolved in toluene (100 ml), a catalytic amount of 10% palladium-carbon (0.5 g) was added thereto, and the mixture was reacted at room temperature to 70° C. under a hydrogen pressure of 3 to 5 atms. in a glass autoclave. After absorption of hydrogen gas ceased, the catalyst was removed by filtration, and the solvent was distilled off under reduced pressure from the filtrate to obtain substantially quantitatively oily 2-fluoro-4-chloro-5-cyclopentyloxyaniline. The spectral data and the like are as described in Reference Example 1.

المصدر