تفاعل #49729

معادلة التفاعل

water

3-fluoro-4-methylaniline

dimethyl disulphide

t-butyl nitrite

3-fluoro-4-methylaniline

t-butyl nitrite

→

2-fluoro-4-(methylsulphenyl)toluene

المذيبات

1,2-dichloroethane

1,2-dichloroethane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas warmed
2. 2
   أخرىthe reaction
3. 3
   درجة الحرارةto maintain the temperature below 60° C
4. 4
   غسيلThe organic layer was washed with water, hydrochloric acid
5. 5
   تجفيفdried (anhydrous magnesium sulphate)
6. 6
   ترشيحfiltered
7. 7
   أخرىThe filtrate was evaporated to dryness
8. 8
   workup.DISTILLATIONthe residue was distilled

الإجراء التجريبي

A mixture of 3-fluoro-4-methylaniline (25 g), dimethyl disulphide (375 g) and t-butyl nitrite (30 ml) in 1,2-dichloroethane was warmed to start the reaction. A solution of 3-fluoro-4-methylaniline (225 g) in 1,2-dichloroethane was added dropwise, simultaneously with t-butyl nitrite (241 ml) at such a rate as to maintain the temperature below 60° C. The mixture was stirred for 2 hours, then water was added. The organic layer was washed with water, hydrochloric acid, dried (anhydrous magnesium sulphate) and filtered. The filtrate was evaporated to dryness and the residue was distilled to give 2-fluoro-4-(methylsulphenyl)toluene (164 g) as a yellow oil; NMR (acetone-d6); 2.2 (3H,d), 2.5 (3H,s), 7.05 (3H,m).

المصدر