تفاعل #49713

معادلة التفاعل

8-chlorooctan-1-ol

sodium iodide

→

8-iodooctan-1-ol

المردود 90.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux overnight
3. 3
   ترشيحThe mixture was filtered
4. 4
   أخرىto remove
5. 5
   أخرىprecipitated sodium chloride
6. 6
   أخرىthe filtrate was evaporated in vacuo
7. 7
   أخرىthe residue partitioned between water (200 ml) and ether (200 ml)
8. 8
   أخرىThe ether layer was separated
9. 9
   غسيلwashed with 1M sodium thoisulfate solution (200 ml)
10. 10
    تجفيفdried over anhydrous magnesium sulfate
11. 11
    ترشيحFiltration, and solvent removal in vacuo

الإجراء التجريبي

A mixture of 8-chlorooctan-1-ol (25 g, 152 mmol) and sodium iodide (125 g, 834 mmol) in acetone (500 ml) was heated at reflux overnight. The mixture was filtered to remove precipitated sodium chloride, the filtrate was evaporated in vacuo, and the residue partitioned between water (200 ml) and ether (200 ml). The ether layer was separated, washed with 1M sodium thoisulfate solution (200 ml), and dried over anhydrous magnesium sulfate. Filtration, and solvent removal in vacuo, afforded 8-iodooctan-1-ol as a colorless oil (34.85 g, 90%).

المصدر