تفاعل #4971

معادلة التفاعل

4-amidinobenzamide hydrochloride

sodium

2-(4-cyanophenyl)-3-methoxyacrolein

→

4-[5-(4-Cyanophenyl)-2-pyrimidinyl]benzamide

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter 15 minutes the solution obtained
2. 2
   ترشيحsuction filtered
3. 3
   غسيلThe residue is washed with water, tetrahydrofuran and diethyl ether
4. 4
   أخرىdried in a high vacuum

الإجراء التجريبي

247 mg of sodium are treated at room temperature with 10 ml of methanol. After 15 minutes the solution obtained is treated at room temperature with 1.58 g of 4-amidinobenzamide hydrochloride. A white suspension forms and this is treated dropwise at room temperature within 10 minutes with a solution of 1.42 g of 2-(4-cyanophenyl)-3-methoxyacrolein in 50 ml of methanol. The reaction mixture is stirred at room temperature for a further 2 hours and then suction filtered. The residue is washed with water, tetrahydrofuran and diethyl ether and dried in a high vacuum. 4-[5-(4-Cyanophenyl)-2-pyrimidinyl]benzamide is obtained.

المصدر