تفاعل #49621

معادلة التفاعل

2-chloro-5-methylnicotinic acid

EDCI

HOBT monohydrate

cumylamine

→

2-chloro-6-methyl-N-(1-methyl-1-phenylethyl)nicotinamide

المردود 62.0%

المذيبات

water

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitated solid was collected by filtration
2. 2
   أخرىdried under reduced pressure

الإجراء التجريبي

In a similar manner to Step 1 of Example 137, 2-chloro-5-methylnicotinic acid (2.00 g, 11.7 mmol) was dissolved in DMF (40 mL), and the solution was treated with EDCI (3.35 g, 17.5 mmol), HOBT monohydrate (890 mg, 5.83 mmol) and cumylamine (3.40 mL, 23.3 mmol). The mixture was added with water. The precipitated solid was collected by filtration and dried under reduced pressure to obtain 2-chloro-6-methyl-N-(1-methyl-1-phenylethyl)nicotinamide (2.09 mg, yield 62%).

المصدر