تفاعل #49620

معادلة التفاعل

trifluoroacetic acid

triethylsilane

hexane ethyl acetate

4,7-dichloro-1-hydroxy-2-(1-methyl-1-phenylethyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one

→

4,7-dichloro-1,2-dihydropyrrolo[3,4-c]pyridine-3-one

المردود 72.0%

المذيبات

nitromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىfollowed by purification by slurry

الإجراء التجريبي

in a similar manner to Step 4 of Example 16, 4,7-dichloro-1-hydroxy-2-(1-methyl-1-phenylethyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (38.8 mg, 0.115 mmol) was dissolved in nitromethane (1.6 mL), and the solution was treated with trifluoroacetic acid (0.177 mL, 2.30 mmol) and triethylsilane (55.1 mL, 0.345 mmol), followed by purification by slurry using chloroform/methanol and by preparative thin-layer chromatography (hexane/ethyl acetate=1/1) to obtain 4,7-dichloro-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (16.8 mg, yield 72%).

المصدر