تفاعل #49618

معادلة التفاعل

cumylamine

triethylamine

2,5-dichloropyridine-3-carbonylchloride

→

2,5-dichloro-N-(1-methyl-1-phenylethyl)nicotinamide

المردود 94.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىfollowed by purification by slurry

الإجراء التجريبي

In a similar manner to Step 1 of Example 16, 2,5-dichloropyridine-3-carbonylchloride (669 mg, 3.19 mmol) was dissolved in dichloromethane (13 mL), and the solution was treated with cumylamine (0.505 mL, 3.51 mmol), triethylamine (0.667 mL, 4.79 mmol) and DMAP (39.0 mg, 0.319 mmol), followed by purification by slurry using diisopropylether/hexane to obtain 2,5-dichloro-N-(1-methyl-1-phenylethyl)nicotinamide (926 mg, yield 94%).

المصدر