تفاعل #49615

معادلة التفاعل

2-bromonicotinic acid

EDCI

HOBT monohydrate

cumylamine

→

2-bromo-N-(1-methyl-1-phenylethyl)nicotinamide

المردود 76.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىfollowed by purification by flash column chromatography (chloroform/methanol=100/1 to 98/2)

الإجراء التجريبي

In a similar manner to Step 1 of Example 137, 2-bromonicotinic acid (2.42 g, 12.0 mmol) was dissolved in DMF (48 mL), and the solution was treated with EDCI (3.45 g, 18.0 mmol), HOBT monohydrate (917 mg, 5.99 mmol) and cumylamine (3.40 mL, 24.0 mmol), followed by purification by flash column chromatography (chloroform/methanol=100/1 to 98/2) to obtain 2-bromo-N-(1-methyl-1-phenylethyl)nicotinamide (2.91 g, yield 76%).

المصدر