تفاعل #49607

معادلة التفاعل

4-Chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride

triethylamine

ethyl isocyanate

→

4-chloro-5-[3-(ethylcarbamoylamino)propoxy]-7-iodoisoindolinone

المردود 93.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىthe residue was purified by slurry

الإجراء التجريبي

4-Chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride (100 mg, 0.248 mmol) was suspended in dichloromethane (3.0 mL), and the suspension was added with triethylamine (0.104 mL, 0.744 mmol) and ethyl isocyanate (0.029 mL, 0.372 mmol), followed by stirring at room temperature for 13 hours. The solvent was evaported under reduced pressure and the residue was purified by slurry using water and acetonitrile to obtain 4-chloro-5-[3-(ethylcarbamoylamino)propoxy]-7-iodoisoindolinone (100 mg, yield 93%).

المصدر