تفاعل #49600

معادلة التفاعل

4-chloro-5-hydroxy-7-iodoisoindolinone

potassium carbonate

(4-bromo-2-methyl-2-butoxy)triethylsilane

→

4-chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone

المردود 35.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىfollowed by purification by flash column chromatography (chloroform/methanol=99/1)

الإجراء التجريبي

In a similar manner to Step 1 of Example 429, 4-chloro-5-hydroxy-7-iodoisoindolinone (70.8 mg, 0.229 mmol) was dissolved in DMF (2.1 mL), and the solution was treated with potassium carbonate (94.8 mg, 0.686 mmol), tetrabutylammonium iodide (8.5 mg, 0.023 mmol) and (4-bromo-2-methyl-2-butoxy)triethylsilane (193 mg, 0.686 mmol), followed by purification by flash column chromatography (chloroform/methanol=99/1) to obtain 4-chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone (40.7 mg, yield 35%).

المصدر