تفاعل #49593

معادلة التفاعل

4-Chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride

triethylamine

methanesulfonyl chloride

→

4-chloro-5-[3-(methanesulfonylamino)propoxy]-7-iodoisoindolinone

المردود 47.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated under reduced pressure
2. 2
   أخرىthe residue was purified by slurry

الإجراء التجريبي

4-Chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride (100 mg, 0.248 mmol) was suspended in dichloromethane (3.0 mL), and the suspension was added with triethylamine (0.104 mL, 0.744 mmol) and methanesulfonyl chloride (0.029 mL, 0.372 mmol), followed by stirring at room temperature for 13 hours. The solvent was evaporated under reduced pressure, and the residue was purified by slurry using water and acetonitrile to obtain 4-chloro-5-[3-(methanesulfonylamino)propoxy]-7-iodoisoindolinone (51.8 mg, yield 47%).

المصدر