تفاعل #49552

معادلة التفاعل

EDCI

HOBT monohydrate

cumylamine

3-methoxymethoxy-4-methylbenzoic acid

→

3-methoxymethoxy-4-methyl-N-(1-methyl-1-phenylethyl)benzamide

المردود 83.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىfollowed by purification by slurry

الإجراء التجريبي

In a similar manner to Step 1 of Example 137, 3-methoxymethoxy-4-methylbenzoic acid (2.69 g) was dissolved in DMF (53 mL), and the solution was treated with EDCI (5.04 g, 26.3 mmol), HOBT monohydrate (2.01 g, 13.1 mmol) and cumylamine (3.80 mL, 26.4 mmol), followed by purification by slurry using hexane to obtain 3-methoxymethoxy-4-methyl-N-(1-methyl-1-phenylethyl)benzamide (3.42 g, yield 83%, 2 steps).

المصدر