تفاعل #49540

معادلة التفاعل

4-Methoxymethoxy-5-dimethoxymethyl-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

hydrogen chloride methanol

→

4-hydroxy-5-formyl-3-methoxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

المردود 79.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated under reduced pressure
2. 2
   workup.DISSOLUTIONthe residue was dissolved in acetonitrile (5 mL)
3. 3
   workup.ADDITIONThe solution was added with 1 mol/L hydrochloric acid (5 mL)
4. 4
   workup.STIRRINGstirred at room temperature for 1 hour
5. 5
   ترشيحThe precipitated solid was collected by filtration
6. 6
   غسيلwashed with water
7. 7
   أخرىby drying under reduced pressure

الإجراء التجريبي

4-Methoxymethoxy-5-dimethoxymethyl-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (490 mg, 0.929 mmol) was dissolved in methanol (10 mL), and the solution was treated with 10% hydrogen chloride-methanol solution (5 mL), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure and the residue was dissolved in acetonitrile (5 mL). The solution was added with 1 mol/L hydrochloric acid (5 mL) and stirred at room temperature for 1 hour. The precipitated solid was collected by filtration and washed with water, followed by drying under reduced pressure to obtain 4-hydroxy-5-formyl-3-methoxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (329 mg, yield 79%).

المصدر