تفاعل #49535

معادلة التفاعل

3-chloro-4-methoxymethoxybenzoic acid

EDCI

HOBT monohydrate

cumylamine

→

3-chloro-4-methoxymethoxy-N-(1-methyl-1-phenylethyl)benzamide

المردود 77.1%

المذيبات

water

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitated solid was collected by filtration
2. 2
   غسيلwashed with water
3. 3
   أخرىby drying under reduced pressure

الإجراء التجريبي

In a similar manner to Step 1 of Example 137, 3-chloro-4-methoxymethoxybenzoic acid (2.39 g, 11.0 mmol) was dissolved in DMF (47 mL), and the solution was treated with EDCI (4.23 g, 22.1 mmol), HOBT monohydrate (1.69 g, 11.0 mmol) and cumylamine (3.20 mL, 22.0 mmol). The reaction mixture was added with water. The precipitated solid was collected by filtration and washed with water, followed by drying under reduced pressure to obtain 3-chloro-4-methoxymethoxy-N-(1-methyl-1-phenylethyl)benzamide (2.83 g, yield 77%).

المصدر