تفاعل #49533

معادلة التفاعل

4-methoxymethoxy-5-dimethoxymethyl-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

trifluoroacetic acid

triethylsilane

→

4-hydroxy-5-methoxymethyl-7-iodoisoindolinone

المردود 86.0%

المذيبات

nitromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىy purification by slurry

الإجراء التجريبي

In a similar manner to Step 4 of Example 16, 4-methoxymethoxy-5-dimethoxymethyl-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (200 mg, 0.379 mmol) was dissolved in nitromethane (10 mL), and the solution was treated with trifluoroacetic acid (0.584 mL, 7.58 mmol) and triethylsilane (0.612 mL, 3.79 mmol), followed y purification by slurry using chloroform to obtain 4-hydroxy-5-methoxymethyl-7-iodoisoindolinone (103 mg, yield-86%).

المصدر