تفاعل #49527

معادلة التفاعل

trifluoroacetic acid

triethylsilane

4-chloro-5-methyl-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

water

→

4-chloro-5-methyl-7-iodoisoindolinone

المردود 67.0%

المذيبات

nitromethane

hexane

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitated solid was collected by filtration
2. 2
   غسيلwashed with hexane and water
3. 3
   أخرىby drying under reduced pressure

الإجراء التجريبي

In a similar manner to Step 4 of Example 16, 4-chloro-5-methyl-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (300 mg, 0.679 mmol) was dissolved in nitromethane (5 mL), and the solution was added with trifluoroacetic acid (0.523 mL, 6.79 mmol) and triethylsilane (0.219 mL, 1.36 mmol), followed by stirring at room temperature for 24 hours. The reaction mixture was added with water, ethyl acetate and hexane. The precipitated solid was collected by filtration and washed with hexane and water, followed by drying under reduced pressure to obtain 4-chloro-5-methyl-7-iodoisoindolinone (140 mg, yield 67%).

المصدر