تفاعل #49525

معادلة التفاعل

3-chloro-4-methylbenzoic acid

EDCI

HOBT monohydrate

cumylamine

→

3-chloro-4-methyl-N-(1-methyl-1-phenylethyl)benzamide

المردود 97.2%

المذيبات

water

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitated solid was collected by filtration
2. 2
   غسيلwashed with water
3. 3
   أخرىby drying under reduced pressure
4. 4
   أخرىThe obtained solid was purified by slurry

الإجراء التجريبي

In a similar manner to Step 1 of Example 137, 3-chloro-4-methylbenzoic acid (1.00 g, 5.86 mmol) was dissolved in DMF (20 mL), and the solution was treated with EDCI (2.25 g, 11.7 mmol), HOBT monohydrate (792 mg, 5.86 mmol) and cumylamine (1.69 mL, 11.7 mmol). The reaction mixture was added with water. The precipitated solid was collected by filtration and washed with water, followed by drying under reduced pressure. The obtained solid was purified by slurry using diisopropylether to obtain 3-chloro-4-methyl-N-(1-methyl-1-phenylethyl)benzamide (1.64 g, yield 97%).

المصدر