تفاعل #49520

معادلة التفاعل

3-hydroxy-4-chloro-5-fluoro-7-iodo-2(1-methyl-1-phenylethyl)isoindolinone

trifluoroacetic acid

triethylsilane

→

4-chloro-5-fluoro-7-iodoisoindolinone

المردود 85.0%

المذيبات

nitromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىfollowed by purification by slurry

الإجراء التجريبي

In a similar manner to Step 4 of Example 16, 3-hydroxy-4-chloro-5-fluoro-7-iodo-2(1-methyl-1-phenylethyl)isoindolinone (806 mg, 1.81 mmol) was dissolved in nitromethane (32 mL), and the solution was treated with trifluoroacetic acid (1.40 mL, 18.1 mmol) and triethylsilane (0.578 mL, 3.62 mmol), followed by purification by slurry using diisopropylether to obtain 4-chloro-5-fluoro-7-iodoisoindolinone (477 mg, yield 85%).

المصدر