تفاعل #49481

معادلة التفاعل

7-amino-4-(3-tert-butyldimethylsilyloxyphenyl)isoindolinone

potassium iodide

iodine

tert-butyl nitrate

→

7-iodo-4-(3-tert-butyldimethylsilyloxyphenyl)isoindolinone

المردود 52.1%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىfollowed by purification by flash column chromatography (chloroform)

الإجراء التجريبي

In a similar manner to Step 4 of Example 140, 7-amino-4-(3-tert-butyldimethylsilyloxyphenyl)isoindolinone (115 mg, 0.324 mmol) was dissolved in acetonitrile (8.0 mL), and the solution was treated with potassium iodide (73.8 mg, 0.441 mmol), copper iodide (84.8 mg, 0.441 mmol), iodine (113 mg, 0.441 mmol) and tert-butyl nitrate (0.071 mL, 0.551 mmol), followed by purification by flash column chromatography (chloroform) to obtain 7-iodo-4-(3-tert-butyldimethylsilyloxyphenyl)isoindolinone (78.6 mg, yield 52%).

المصدر