تفاعل #49398

معادلة التفاعل

triethylamine

4-chloro-7-iodoisoindolinone

1-(tert-butoxycarbonyl)-5-cyanoindole-2-boronic acid

→

4-chloro-7-[1-(tert-butoxycarbonyl)-5-cyanoindol-2-yl]isoindolinone

المردود 42.9%

المذيبات

hexane ethyl acetate

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىsynthesized in a similar manner to the method

الإجراء التجريبي

In a similar manner to Step 2 of Example 1, 4-chloro-7-iodoisoindolinone (68.4 mg, 0.230 mmol) was dissolved in acetonitrile (1.4 mL), and the solution was treated with 1-(tert-butoxycarbonyl)-5-cyanoindole-2-boronic acid (100 mg, 0.350 mmol) synthesized in a similar manner to the method described in Journal of Organic Chemistry, 2002, vol. 67, p. 7551, palladium acetate (4.1 mg, 0.018 mmol) and triethylamine (0.321 mL, 2.30 mmol), followed by purification by preparative thin-layer chromatography (hexane/ethyl acetate=1/1) to obtain 4-chloro-7-[1-(tert-butoxycarbonyl)-5-cyanoindol-2-yl]isoindolinone (40.2 mg).

المصدر