تفاعل #49391

معادلة التفاعل

4-chloro-7-iodoisoindolinone

2-benzofuraneboronic acid

tri(o-tolyl)phosphine

triethylamine

→

Compound 170

المردود 18.5%

4-Chloro-7-(benzofuran-2-yl)isoindolinone

المردود 18.5%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىfollowed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=15/1)

الإجراء التجريبي

In a similar manner to Step 2 of Example 1, 4-chloro-7-iodoisoindolinone (80.0 mg, 0.273 mmol) was dissolved in acetonitrile (4.0 mL), and the solution was treated with 2-benzofuraneboronic acid (133 mg, 0.819 mmol), palladium acetate (7.4 mg, 0.033 mmol), tri(o-tolyl)phosphine (20 mg, 0.066 mmol) and triethylamine (0.381 mL, 2.73 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=15/1) to obtain Compound 170 (14.3 mg, yield 18%).

المصدر