تفاعل #49381

معادلة التفاعل

triethylamine

4-chloro-7-iodoisoindolinone

→

Compound 156

المردود 164.2%

4-Chloro-7-(1-methylindol-2-yl)isoindolinone

المردود 164.2%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىfollowed by purification by flash column chromatography (hexane/ethyl acetate=7/3, 3/2, 1/1)

الإجراء التجريبي

In a similar manner to Step 2 of Example 1, 4-chloro-7-iodoisoindolinone (84.0 mg, 0.286 mmol) was dissolved in acetonitrile (3 mL), and the solution was treated with Compound BK (100 mg, 0.571 mmol), palladium acetate (5.2 mg, 0.023 mmol) and triethylamine (0.400 mL, 2.87 mmol), followed by purification by flash column chromatography (hexane/ethyl acetate=7/3, 3/2, 1/1) to obtain Compound 156 (69.7 mg, yield 82%).

المصدر