تفاعل #49380

معادلة التفاعل

7-amino-4-(4-hydroxy-3-methoxyphenyl)isoindolinone

potassium iodide

iodine

tert-butyl nitrite

→

7-iodo-4-(4-hydroxy-3-methoxy-5-nitrophenyl)isoindolinone

المردود 31.4%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىfollowed by purification by preparative thin-layer chromatography (chloroform/methanol=15/1)

الإجراء التجريبي

In a similar manner to Step 4 of Example 140, 7-amino-4-(4-hydroxy-3-methoxyphenyl)isoindolinone (202 mg, 0.747 mmol) was dissolved in acetonitrile (10.1 mL), and the solution was treated with potassium iodide (149 mg, 0.896 mmol), copper iodide (171 mg, 0.896 mmol), iodine (228 mg, 0.896 mmol) and tert-butyl nitrite (0.266 mL, 0.896 mmol), followed by purification by preparative thin-layer chromatography (chloroform/methanol=15/1) to obtain 7-iodo-4-(4-hydroxy-3-methoxy-5-nitrophenyl)isoindolinone (100 mg, yield 31%).

المصدر